Bilayer Matrix Tablets for Prolonged Actions of Metformin Hydrochloride and Repaglinide
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چکیده
منابع مشابه
Metformin Hydrochloride Tablets
CLINICAL PHARMACOLOGY Mechanism of Action Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucos...
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DESCRIPTION GLUCOPHAGE (metformin hydrochloride) Tablets and GLUCOPHAGE XR (metformin hydrochloride) Extended-Release Tablets are oral antihyperglycemic drugs used in the management of type 2 diabetes. Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. The structura...
متن کاملDevelopment and in Vitro Evaluation of Sustained Release Floating Matrix Tablets of Metformin Hydrochloride
Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointest...
متن کاملFormulation of Sustained Release Matrix Tablets of Metformin hydrochloride by Polyacrylate Polymer
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متن کاملFormulation and Evaluation of Bilayer Floating Matrix Tablets For Captopril
The importance of the present investigation was to formulate a bilayer-floating tablet (BFT) for captopril using direct compression technology. The release layer contained captopril and various polymers such as HPMC-K15M, PVP-K30 and Carbopol 934p, alone or in combination with the drug. HPMC, K-grade and effervescent mixture of citric acid and sodium bicarbonate formed the floating layer. The f...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2014
ISSN: 1530-9932
DOI: 10.1208/s12249-014-0229-1